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Legislation Reform Needed Update:

NOTE:  The new section is not intended to take the place of seeing a physician for a consultation.  

Case Example:  Period stopped after UAE (age 48)

I had the UAE procedure performed two years ago (age 48 years).  The result was that I went straight into menopause.  My period stopped cold!  Prior to the surgery my "female" hormone levels were normal (not in the perimenopausal or menopausal range).

Almost immediately after the UAE procedure, I developed high blood pressure for which I am now taking meds, hot flashes, night sweats, and I gained some 30 lbs.   I have fat everywhere that has been impossible to lose.  Although I am no longer bleeding and anemic, my post-UAE experience has been and continues to be miserable.

Analysis:  There has been a documented %5+ incidence of menopause post UAE that is overwhelmingly seen in women 45 y/o or over.  The theory is that since these women are within the normal age of menopause:

·     Some coincidentally were fated to go into menopause at that time – which is not reliably predicted by any but very specialized hormone analysis or

·     The particles used for UAE that normally enter the arteries supplying the ovaries in this aging ovary are sufficient to precipitate menopause. 

Weight gain, hot flashes and sweats are typical symptoms for many women in menopause.  This is not to make light of what has happened but this was predictably what was about to happen sooner rather that later in a woman in this age group whether she had had 'UAE or not. 

All these symptoms should be discussed with a gyn.  It is unfortunate when this is not effectively explained to a woman >45 before the procedure.  – Francis Hutchins, M.D.

Medical Article:  Spies JB, Roth AR, Gonsalves SM, Murphy-Skrzyniarz KM. "Ovarian Function after Uterine Artery Embolization for Leiomyomata: Assessment with Use of Serum Follicle Stimulating Hormone Assay", Entrez PubMed,  Interventional Radiology Section, Department of Radiology of Georgetown University Hospital, 3800 Reservoir Rd. NW, GC 201, Washington, DC 20007-2197, USA.

CONCLUSIONS: Most patients had no change in ovarian function as measured by basal FSH after UAE.  For patients aged 45 or older, there is approximately a 15% chance of an increase in basal FSH into the perimenopausal range.

 

Case Example:  UAE, Myomectomy, IVF (implant)

I had a myomectomy in 2005, but I still have 6 fibroids left and they are located in areas that will still prevent me from getting pregnant.  Is UAE, another myomectomy, or IVF (implant) my best option?

Analysis:  My first suggestion would be to make sure that there is no question that you need to have these fibroids treated to become pregnant.  This is an area of controversy.  It is clear that fibroids that are growing into the cavity of the uterus can be a threat to conception as well as a developing pregnancy.  If you had these you would be experiencing very heavy periods.  Also if the uterus is very enlarged, for example the size of a 5-month pregnancy, the shear bulk might make carrying a pregnancy very difficult. 

Assuming you need to have some treatment, UAE is at present an option; especially since you have had a previous myomectomy.  Repeat myomectomies in general are much more difficult and tend to have more complications.  There has been a debate until recently as to whether UAE is acceptable for women seeking future pregnancy.  My review of the literature and my experience suggest that it is appropriate - particularly as an alternative to a repeat myomectomy. 

It depends on a number of factors.  Any reluctance arises from their concern that IVF with embryo implantation is very expensive and the risk of miscarriage is elevated with fibroids.  You should discuss this at length with a fertility specialist and be willing to get a second opinion. – Francis Hutchins, M.D.

 

Case Example:  Pregnancy and fibroid

I am 19 weeks pregnant, and the doctor said the placenta is attached to a 12cm fibroid. 

Analysis:  If the placenta attaches over a fibroid the significance depends on the size of the fibroid, the amount of the placenta that is attached to it and whether the fibroid is deep in the wall or protruding from the wall into the cavity of the uterus.   Depending on the answers to these questions this situation can be quite serious for the baby.   Fortunately, as the pregnancy progresses the portion of the placenta over the fibroid may move away due to the growth of the uterus.   In this case, one would expect the problem to go away.  -  Francis Hutchins, M.D.

Refer to The Story Behind The Fibroid Photo, Fibroids and Pregnancy
 


 

Case Example:  Fibroids, Pregnancy, Abortion

I am 3 months pregnant, still in pain, and considering terminating the pregnancy.  I have multiple fibroids that are as follows: right side measures over 7cm, left side around 7, and one on top of my uterus.  The right fibroid is partly blocking my cervix.  I was informed that this might cause complications during the abortion.  I am getting conflicting viewpoints from my doctors.  I am concerned about keeping my fertility.

Analysis:  Your first decision involves choosing a competent physician.  Then leave the mechanics such as where the procedure should be done to that physician.  That is the kind of technical input that you are paying for.  Yes, fibroids can complicate the performance of an abortion. 

The decision is yours and all the opinions in the world will not change that.  There is risk with everything in life and certainly with medical treatment.  In spite of this, the overwhelming majority of women who undergo a termination at this stage of pregnancy undergo it safely and their fertility is not affected.  -  Francis Hutchins, M.D.

Refer to Pregnancy and Fibroids:  Pregnancy and Contraception.
 


 

Case Example:  Pregnancy, Pain, Medications

I am currently 13 weeks pregnant, in a lot of pain and unsure of what to do with regard to my pregnancy.  I have uterine fibroids, which caused me pain before my pregnancy.   I was told it would be difficult for me to get pregnant due to my age (35) and the fibroids.  So the pregnancy was definitely a surprise.  The pain has been excruciating at times and I have not been able to work because I am so uncomfortable.  I am currently taking ibuprofen for pain.  In the severe episodes I have taken Darvocet and was even given a shot of Demerol.  I am very concerned about the effect of the medication on the baby and about moving forward with the pregnancy knowing I may be in this much pain and this uncomfortable.  I am also scared if I don't try to carry the baby because my OB/Gyn has made me feel like this may be my only chance to have a baby.  I don't know if that is true.  I really need some more information regarding my options for pain relief, the possible effects on my pregnancy, and my fertility in general.  I also am scared about the effects of termination on my health and future fertility.

Analysis:  The most important fact for you to remember is that pain from fibroid degeneration at this stage is not unusual and you are taking the standard drugs, ibuprofen and Demerol, used to treat this.  They have been used without harm to pregnancy. 

The good news is that this pain tends to get better and often resolves at or about 24 weeks of gestation. 

Pregnancy termination is considered one of the safest procedures in medicine but that is not to say that complication won’t occur to somebody sometime. Your fertility at this point appears to be intact since you are pregnant.  If this pregnancy is not carried you will still be faced with the need for removal of the tumors and that could interfere with fertility because of scarring.

I think you need to seek support through a close relationship with a caring OB/Gyn or other support person.  Most of these pregnancies turn out well but occasionally termination is chosen.
 -  Francis Hutchins, M.D.


 

Case Example:  Fibroid Growth After A Myomectomy

I had an abdominal myomectomy June 2005, at which time nine (9) fibroids were removed.   Now, in Dec. 2005, I have new fibroids.  I am wondering how unusual this is?  My surgeon said he removed all the fibroids he could see and feel.   Is it possible the doctor missed some?  Should I be concerned about my hormones, particularly estrogen, if fibroids are growing this fast after a myomectomy?  I realize I need to visit my doctor, but I am trying to understand why my fibroids and bulk symptoms would return so soon after myomectomy.

Analysis:  I wonder how you know that your fibroids have recurred.  Ultrasound, MRI, examination or possibly you are basing this on symptoms.   If it is symptoms that can be very unreliable since many things can cause similar symptoms.

A fibroid uterus usually contains many fibroids some because of size are very obvious.  Others are very small and difficult to see.  In addition, to remove all fibroids can be quite challenging because it may require such extensive dissection as to result for all practical purposes in destruction of the uterus.

Therefore, the goal of myomectomy is to;

1.    remove all symptomatic tumors

2.   remove all obvious tumors that could predictably lead to further problems in the near future. 

It is always the goal to remove all tumors if feasible. Even if all tumors are removed it is recognized that there is the possibility of recurrence because

1.    some tumors are too small to be seen

2.   the uterus will always retain the genetic basis for forming fibroids again. 

I agree, it is surprising that you would have a recurrence so soon but first it must be confirmed.  Francis Hutchins, M.D.


 

Case Example:  Bleeding, Endometrial Ablation, and Alternatives

I am in my late 40’s and I have had heavy bleeding for approximately two years.  It started out lasting a week and now it lasts for three weeks out of the month.  I was given all the tests and a couple of small fibroids were discovered.  I tried an Endometrial Ablation, but the fluid going in wasn't coming out so my doctor stopped the procedure.  Other doctors have said that ablation won't work with fibroids but I don't know if it will or not.  I am now on a low dose of birth control pills and for 3-4 months the pills seemed to be working.  Recently I have been  experiencing bleeding problems again even with being on the pill.  I am trying to find a way to get to menopause naturally.  I  would like to avoid a hysterectomy if possible, but I am feeling like I don't have other treatment options available for my situation.

Analysis:  You would appear to potentially have several options all of which would not include hysterectomy: 

  •  Adjust birth control pill dosage.
     
  •  Endometrial Ablation coupled – the fact that there was difficulty with fluid control only applies to that one attempt and the operator.  Fluid control is usually manageable.
     
  • Global Ablation – new group of techniques many of which can treat fibroids in the cavity which you likely have.
     
  • MRI Focused ultrasound – new, not universally available and expensive.
     
  • Uterine Artery Embolization – very effective for bleeding with fibroids.
     
  • Hormonal therapy with potent progestin.
     
  • Lupron (GnRH analogue) – can be given intermittently for 3-6 months at a time.

As you can see there are potentially many alternatives.  Much of this is dependant on the Gyn you are working with.  Francis Hutchins, M.D.

Analysis:  Many women with fibroids can have a successful endometrial ablation, especially if they are close to menopause.  In this case, the fluid problem makes me think that the gynecologist did not have the experience to do such a procedure.  Ablation, especially in the presence of fibroids, requires a great deal of experience and skill in hysteroscopic surgery.  This is not something that most gynecologists will have.  Years ago I published a series of hysteroscopic treatment of abnormal bleeding in women with fibroids with excellent overall results. (1) In order to make the proper decision on how to treat heavy bleeding you should see a gynecologist who is knowledgeable about all surgical and non-surgical options.  - Paul Indman, M.D. 

Medical Article:  Indman PD.  Hysteroscopic treatment of menorrhagia associated with uterine leiomyomas. (Entrez Pubmed) Obstet Gynecol. 1993 May;81(5 ( Pt 1)):716-20.

OBJECTIVE: To determine the effectiveness of hysteroscopic treatment of menorrhagia associated with uterine leiomyomas.  CONCLUSION: Hysteroscopic treatment of menorrhagia associated with uterine myomas can be effective in carefully selected patients.


 

Case Example:  Asymptomatic Uterine Fibroids and Fertility

I discovered last year that I have three fibroids - two small intramural and one large serous (9cm).  Apart from some pressure symptoms about a week before a period (bladder pressure and some back pain) I am virtually asymptomatic.  My GP suggested I leave them alone whereas my Gyn wants me to be more proactive.

Part of me is reluctant to go through any procedure which would cause any pain or discomfort and which may reduce whatever fertility I have left (I'm 39).  At the same time I don't want to wait until it gets so large that it is putting even more pressure on my organs and I would be of an age where there was an increased risk of premature menopause.  If I opt for any treatment I would prefer embolization.

Analysis:  The primary indication for treatment of fibroids is to improve symptoms.  It does not appear that your symptoms are an issue for you.

It might not continue to grow.  Even if it does grow it may do so at a very slow rate.  If it does grow it may not be any more symptomatic.  If it does become symptomatic you still would likely be a candidate for conservative therapy such as UAE. 

I am being the devil’s advocate in order to give you a perspective.  These thing are not very predictable and the downside risk is not necessarily that great.  

You are correct regarding fertility.  There is a risk that should you have surgery or any other intervention your fertility may be decreased assuming that your fertility is intact now. 

I hope I have added to your understanding but I also realize that more information may cause you more confusion.  Nevertheless knowledge is always good.  If you are undecided, sit back and cogitate for a while and continue your search for the truth.   Francis Hutchins, M.D.

Pregnancy - Fertility continued Page: #3b

 


Francis L. Hutchins, Jr. is a Gynecologist - Plymouth Meeting, PA (Philadelphia).
 Francis Hutchins, Jr.,  M.D.

Paul Indman, M.D. is a Gynecologist in Los Gatos, CA.
Paul Indman, M.D.


CASE
EXAMPLES (#3)
Fertility/Pregnancy   

Period stopped after UAE

UAE, Myomectomy, IVF (implant)

Placenta attached to fibroid
Fibroids, Pregnancy, Abortion
Pregnancy, Pain, Medications
Fibroid growth after Myomectomy
Bleeding, Endometrial Ablation, Alternatives
Asymptomatic Uterine Fibroids and Fertility


Case: #1

Case: #2
Case: #3b
Case: #4 Menopause
Case: #5

Case Listing

Pedunculated Fibroid Photo


Medical Terms
Notes On Insurance

 

 

 

 

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Legal Note:  The material presented on Hope For Fibroids, Inc. web site is for informational purposes only.  It is not meant to be a substitute for physician care.  If you need medical advice on uterine fibroid disease or other medical conditions you should discuss them with a physician.
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